Assay Detail
Binding
CHEMBL645668
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Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Forskolin carbamates: binding and activation studies with type I adenylyl cyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.86 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328689 | — | — | 1 | 7.68 |
| CHEMBL328561 | — | — | 1 | 7.51 |
| CHEMBL92229 | — | — | 1 | 7.50 |
| CHEMBL329247 | — | — | 1 | 7.44 |
| CHEMBL93009 | — | — | 1 | 7.41 |
| CHEMBL52606 | COLFORSIN | 2.0 | 1 | 7.39 |
| CHEMBL317990 | — | — | 1 | 7.37 |
| CHEMBL432817 | — | — | 1 | 7.36 |
| CHEMBL93259 | — | — | 1 | 7.19 |
| CHEMBL93242 | — | — | 1 | 7.19 |
| CHEMBL92911 | — | — | 1 | 7.14 |
| CHEMBL329916 | — | — | 1 | 7.12 |
| CHEMBL328358 | — | — | 1 | 7.12 |
| CHEMBL430458 | — | — | 1 | 7.09 |
| CHEMBL93521 | — | — | 1 | 7.05 |
| CHEMBL327672 | — | — | 1 | 7.02 |
| CHEMBL93260 | — | — | 1 | 6.95 |
| CHEMBL94343 | — | — | 1 | 6.93 |
| CHEMBL92577 | — | — | 1 | 6.93 |
| CHEMBL94313 | — | — | 1 | 6.91 |
| CHEMBL91909 | — | — | 1 | 6.89 |
| CHEMBL330054 | — | — | 1 | 6.85 |
| CHEMBL92857 | — | — | 1 | 6.84 |
| CHEMBL93393 | — | — | 1 | 6.80 |
| CHEMBL93252 | — | — | 1 | 6.79 |
| CHEMBL90423 | — | — | 1 | 6.78 |
| CHEMBL327612 | — | — | 1 | 6.77 |
| CHEMBL94168 | — | — | 1 | 6.76 |
| CHEMBL93194 | — | — | 1 | 6.74 |
| CHEMBL89962 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328689 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL328561 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL92229 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL329247 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL93009 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL52606 | COLFORSIN | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL317990 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL432817 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL93259 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL93242 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL92911 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL328358 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL329916 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL430458 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL93521 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL327672 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL93260 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL94343 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL92577 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL94313 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL91909 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL330054 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL92857 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL93393 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL93252 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL90423 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL327612 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL94168 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL93194 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL89962 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL92919 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL327697 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL93042 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL92719 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL93841 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL93468 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL93469 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL420432 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL94135 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL317534 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL330704 | — | IC50 | = | 555.0 | nM | 6.26 |
| CHEMBL419139 | — | IC50 | = | 593.0 | nM | 6.23 |
| CHEMBL91795 | — | IC50 | = | 608.0 | nM | 6.22 |
| CHEMBL93408 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL92687 | — | IC50 | = | 1600.0 | nM | 5.80 |