Assay Detail
Binding
CHEMBL645683
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In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
2,4-Diamino-6,7-dimethoxyquinazolines. 2. 2-(4-Carbamoylpiperidino) derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 9.04 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6424 | — | — | 1 | 10.00 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.72 |
| CHEMBL415288 | — | — | 1 | 9.70 |
| CHEMBL6474 | — | — | 1 | 9.66 |
| CHEMBL266317 | — | — | 1 | 9.38 |
| CHEMBL267457 | — | — | 1 | 9.33 |
| CHEMBL6380 | — | — | 1 | 9.33 |
| CHEMBL6598 | — | — | 1 | 9.20 |
| CHEMBL6766 | — | — | 1 | 9.19 |
| CHEMBL6556 | — | — | 1 | 9.17 |
| CHEMBL6481 | — | — | 1 | 9.10 |
| CHEMBL6447 | — | — | 1 | 9.05 |
| CHEMBL269537 | — | — | 1 | 8.97 |
| CHEMBL267705 | — | — | 1 | 8.96 |
| CHEMBL267164 | — | — | 1 | 8.95 |
| CHEMBL6610 | — | — | 1 | 8.94 |
| CHEMBL6789 | — | — | 1 | 8.85 |
| CHEMBL266927 | — | — | 1 | 8.84 |
| CHEMBL268627 | — | — | 1 | 8.79 |
| CHEMBL6431 | — | — | 1 | 8.76 |
| CHEMBL266279 | — | — | 1 | 8.08 |
| CHEMBL6831 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6424 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL2 | PRAZOSIN | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL415288 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL6474 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL266317 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL267457 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL6380 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL6598 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL6766 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL6556 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL6481 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL6447 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL269537 | — | Ki | = | 1.08 | nM | 8.97 |
| CHEMBL267705 | — | Ki | = | 1.11 | nM | 8.96 |
| CHEMBL267164 | — | Ki | = | 1.13 | nM | 8.95 |
| CHEMBL6610 | — | Ki | = | 1.14 | nM | 8.94 |
| CHEMBL6789 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL266927 | — | Ki | = | 1.46 | nM | 8.84 |
| CHEMBL268627 | — | Ki | = | 1.64 | nM | 8.79 |
| CHEMBL6431 | — | Ki | = | 1.73 | nM | 8.76 |
| CHEMBL266279 | — | Ki | = | 8.25 | nM | 8.08 |
| CHEMBL6831 | — | Ki | = | 116.73 | nM | 6.93 |