Assay Detail
Binding
CHEMBL645685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potency to displace [3H]- WB-4101 from alpha-1 adrenergic receptor in rat striatum
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.97 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58792 | FLUANISONE | 2.0 | 1 | 9.06 |
| CHEMBL58613 | — | — | 1 | 8.82 |
| CHEMBL58377 | — | — | 1 | 8.05 |
| CHEMBL294633 | — | — | 1 | 8.01 |
| CHEMBL418140 | — | — | 1 | 7.24 |
| CHEMBL292187 | ELOPIPRAZOLE | 2.0 | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58792 | FLUANISONE | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL58613 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL58377 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL294633 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL418140 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL292187 | ELOPIPRAZOLE | Ki | = | 220.0 | nM | 6.66 |