Assay Detail
Binding
CHEMBL645687
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Tested for its binding affinity against alpha-1 receptor in rat brain membrane
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.95 | 6.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL544765 | — | — | 1 | 6.73 |
| CHEMBL306751 | — | — | 3 | 6.51 |
| CHEMBL77921 | MEDETOMIDINE | 3.0 | 1 | 5.96 |
| CHEMBL542155 | — | — | 1 | 5.03 |
| CHEMBL75022 | — | — | 1 | 4.80 |
| CHEMBL553835 | — | — | 1 | - |
| CHEMBL541302 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL544765 | — | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL306751 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL306751 | — | Ki | = | 461.0 | nM | 6.34 |
| CHEMBL306751 | — | Ki | = | 536.0 | nM | 6.27 |
| CHEMBL77921 | MEDETOMIDINE | Ki | = | 1102.0 | nM | 5.96 |
| CHEMBL542155 | — | Ki | = | 9255.0 | nM | 5.03 |
| CHEMBL75022 | — | Ki | = | 15902.0 | nM | 4.80 |
| CHEMBL553835 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL541302 | — | Ki | > | 50000.0 | nM | - |