Assay Detail
Binding
CHEMBL645688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested in vitro for binding affinity by measuring its ability to inhibit [3H]prazosin binding at alpha-1 adrenergic receptor in rat cerebral cortex membranes.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparison of CoMFA models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 7.17 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289873 | — | — | 1 | 8.51 |
| CHEMBL42810 | — | — | 1 | 8.08 |
| CHEMBL46881 | — | — | 1 | 8.07 |
| CHEMBL290039 | — | — | 1 | 8.02 |
| CHEMBL43992 | — | — | 1 | 8.00 |
| CHEMBL296413 | — | — | 1 | 7.98 |
| CHEMBL41978 | — | — | 1 | 7.94 |
| CHEMBL42644 | — | — | 1 | 7.92 |
| CHEMBL290203 | — | — | 1 | 7.81 |
| CHEMBL44786 | — | — | 1 | 7.75 |
| CHEMBL42404 | — | — | 1 | 7.73 |
| CHEMBL416984 | — | — | 1 | 7.67 |
| CHEMBL46677 | — | — | 1 | 7.60 |
| CHEMBL45007 | — | — | 1 | 7.59 |
| CHEMBL43332 | — | — | 1 | 7.58 |
| CHEMBL46885 | — | — | 1 | 7.33 |
| CHEMBL46918 | — | — | 1 | 7.19 |
| CHEMBL417709 | — | — | 1 | 7.14 |
| CHEMBL45253 | — | — | 1 | 7.04 |
| CHEMBL42706 | — | — | 1 | 6.96 |
| CHEMBL296713 | — | — | 1 | 6.88 |
| CHEMBL46535 | — | — | 1 | 6.72 |
| CHEMBL47040 | — | — | 1 | 6.61 |
| CHEMBL46525 | — | — | 1 | 6.43 |
| CHEMBL46802 | — | — | 1 | 6.30 |
| CHEMBL47200 | — | — | 1 | 5.41 |
| CHEMBL42396 | — | — | 1 | 5.36 |
| CHEMBL298286 | — | — | 1 | 5.18 |
| CHEMBL46377 | — | — | 1 | 5.12 |
| CHEMBL1202594 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289873 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL42810 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL46881 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL290039 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL43992 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL296413 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL41978 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL42644 | — | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL290203 | — | Ki | = | 15.4 | nM | 7.81 |
| CHEMBL44786 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL42404 | — | Ki | = | 18.6 | nM | 7.73 |
| CHEMBL416984 | — | Ki | = | 21.6 | nM | 7.67 |
| CHEMBL46677 | — | Ki | = | 25.2 | nM | 7.60 |
| CHEMBL45007 | — | Ki | = | 25.8 | nM | 7.59 |
| CHEMBL43332 | — | Ki | = | 26.4 | nM | 7.58 |
| CHEMBL46885 | — | Ki | = | 47.2 | nM | 7.33 |
| CHEMBL46918 | — | Ki | = | 64.9 | nM | 7.19 |
| CHEMBL417709 | — | Ki | = | 72.4 | nM | 7.14 |
| CHEMBL45253 | — | Ki | = | 90.4 | nM | 7.04 |
| CHEMBL42706 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL296713 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL46535 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL47040 | — | Ki | = | 247.0 | nM | 6.61 |
| CHEMBL46525 | — | Ki | = | 375.0 | nM | 6.43 |
| CHEMBL46802 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL47200 | — | Ki | = | 3935.0 | nM | 5.41 |
| CHEMBL42396 | — | Ki | = | 4325.0 | nM | 5.36 |
| CHEMBL298286 | — | Ki | = | 6652.0 | nM | 5.18 |
| CHEMBL46377 | — | Ki | = | 7533.0 | nM | 5.12 |
| CHEMBL1202594 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL42219 | — | Ki | = | 199000.0 | nM | - |
| CHEMBL46651 | — | Ki | = | 260000.0 | nM | - |