Assay Detail
Binding
CHEMBL645690
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The binding affinity at Alpha-1 adrenergic receptor determined using [3H]prazosin
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.74 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 7.55 |
| CHEMBL113238 | — | — | 1 | 7.13 |
| CHEMBL324270 | — | — | 1 | 7.08 |
| CHEMBL111184 | — | — | 1 | 6.69 |
| CHEMBL334270 | — | — | 1 | 6.00 |
| CHEMBL654 | MIRTAZAPINE | 4.0 | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6437 | MIANSERIN | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL113238 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL324270 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL111184 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL334270 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL654 | MIRTAZAPINE | Ki | = | 1050.0 | nM | 5.98 |