Assay Detail
Binding
CHEMBL645745
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat midbrain angiotensin II type 2 receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Subtituted phenylthiophene benzoylsulfonamides with potent binding affinity to angiotensin II AT1 and AT2 receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.71 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293511 | — | — | 1 | 8.52 |
| CHEMBL300154 | — | — | 1 | 7.66 |
| CHEMBL7550 | L-158809 | — | 1 | 7.43 |
| CHEMBL292829 | — | — | 1 | 6.92 |
| CHEMBL56549 | — | — | 1 | 6.89 |
| CHEMBL293949 | — | — | 1 | 6.82 |
| CHEMBL57853 | — | — | 1 | 6.82 |
| CHEMBL299897 | — | — | 1 | 6.72 |
| CHEMBL58499 | — | — | 1 | 6.05 |
| CHEMBL58291 | — | — | 1 | 5.40 |
| CHEMBL57976 | — | — | 1 | 4.60 |
| CHEMBL58156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293511 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL300154 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL7550 | L-158809 | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL292829 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL56549 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL293949 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL57853 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL299897 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL58499 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL58291 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL57976 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL58156 | — | IC50 | > | 30.0 | nM | - |