Compound Detail
CHEMBL293949
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CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1
Basic Information
| ChEMBL ID | CHEMBL293949 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NOCPYKVHPZVKJD-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
600.8
MW (Da)
7.24
ALogP
7
HBA
1
HBD
94.0
PSA (Ų)
0.16
QED
2
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Type-1 angiotensin II receptor CHEMBL3948 | IC50 | 8.12 | 8.12 | 7.5 | 1 |
| Type-2 angiotensin II receptor CHEMBL257 | IC50 | 6.82 | 6.82 | 150.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Type-1 angiotensin II receptor | IC50 | = | 7.5 | nM | 8.12 | Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay | - |
| Type-2 angiotensin II receptor | IC50 | = | 150.0 | nM | 6.82 | Inhibition of rat midbrain angiotensin II type 2 receptor | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)81145-8 | Type-1 angiotensin II receptor | 1 |
| - | 10.1016/S0960-894X(01)81145-8 | Type-2 angiotensin II receptor | 1 |
Data from ChEMBL 36 via Core Engine