Assay Detail
Binding
CHEMBL645780
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Ability to displace specific radioligand [125I]AB-MECA binding at human Adenosine A3 receptor expressed in CHO cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.22 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27376 | — | — | 1 | 8.82 |
| CHEMBL280580 | — | — | 1 | 8.62 |
| CHEMBL283057 | — | — | 1 | 8.21 |
| CHEMBL286739 | — | — | 1 | 7.65 |
| CHEMBL27443 | — | — | 1 | 7.52 |
| CHEMBL26759 | — | — | 1 | 7.07 |
| CHEMBL27952 | — | — | 1 | 6.77 |
| CHEMBL28057 | — | — | 1 | 6.04 |
| CHEMBL27593 | — | — | 1 | 5.96 |
| CHEMBL27502 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27376 | — | Ki | = | 1.51 | nM | 8.82 |
| CHEMBL280580 | — | Ki | = | 2.39 | nM | 8.62 |
| CHEMBL283057 | — | Ki | = | 6.19 | nM | 8.21 |
| CHEMBL286739 | — | Ki | = | 22.5 | nM | 7.65 |
| CHEMBL27443 | — | Ki | = | 29.9 | nM | 7.52 |
| CHEMBL26759 | — | Ki | = | 84.7 | nM | 7.07 |
| CHEMBL27952 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL28057 | — | Ki | = | 912.0 | nM | 6.04 |
| CHEMBL27593 | — | Ki | = | 1090.0 | nM | 5.96 |
| CHEMBL27502 | — | Ki | = | 2880.0 | nM | 5.54 |