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Compound Detail

CHEMBL28057

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OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(I)c4)nc(Cl)nc31)C[C@@H]2O

Basic Information

ChEMBL ID CHEMBL28057
Phase Preclinical
Structure Type MOL
InChI Key BWHAIDUMUGNTQL-BZIRYSOJSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

511.8
MW (Da)
3.00
ALogP
7
HBA
3
HBD
96.1
PSA (Ų)
0.36
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H19ClIN5O2
MW 511.75
Aromatic Rings 3
Heavy Atoms 28
NP-Likeness -0.04

Activity Summary

Ki 3 meas. best 6.04

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
Ki 6.04 6.04 912.0 1
Adenosine receptor A1
CHEMBL318
Ki 5.06 5.06 8730.0 1
Adenosine receptor A2a
CHEMBL302
Ki 4.59 4.59 25400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11392549 10.1016/s0960-894x(01)00213-x Adenosine receptor A1 1
11392549 10.1016/s0960-894x(01)00213-x Adenosine receptor A2a 1
11392549 10.1016/s0960-894x(01)00213-x Adenosine receptor A3 1

Data from ChEMBL 36 via Core Engine