Assay Detail
Binding
CHEMBL646356
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Ability to displace specific radioligand [3H]-CGS- 21680 binding at A2A receptors (rA2A) in rat brain membrane
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.66 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280580 | — | — | 1 | 6.26 |
| CHEMBL417292 | — | — | 1 | 6.22 |
| CHEMBL27809 | — | — | 1 | 6.13 |
| CHEMBL27376 | — | — | 1 | 5.78 |
| CHEMBL284216 | — | — | 1 | 5.47 |
| CHEMBL27952 | — | — | 1 | 5.17 |
| CHEMBL28057 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280580 | — | Ki | = | 548.0 | nM | 6.26 |
| CHEMBL417292 | — | Ki | = | 601.0 | nM | 6.22 |
| CHEMBL27809 | — | Ki | = | 732.0 | nM | 6.13 |
| CHEMBL27376 | — | Ki | = | 1660.0 | nM | 5.78 |
| CHEMBL284216 | — | Ki | = | 3390.0 | nM | 5.47 |
| CHEMBL27952 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL28057 | — | Ki | = | 25400.0 | nM | 4.59 |