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Evidence Snapshot

Adenosine receptor A2a

CHEMBL302 SINGLE PROTEIN Rattus norvegicus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:19:57Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL302
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Adenosine receptor A2a as ChEMBL target CHEMBL302, mapped to UniProt P30543. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Adenosine receptor A2a
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL302
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P30543
Adenosine receptor A2a
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Adenosine receptor A2a matters

As of 2026-09-13

Adenosine receptor A2a is reviewed as Adenosine receptor A2a (UniProt P30543); the current evidence base includes 10 approved drugs, 2563 compounds, and 354 assays, with lead potency reaching pChEMBL 10.3.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 10 approved drugs, 2563 compounds, and 354 assays for this target. The dominant activity type is KI. CHEMBL2111930 is the current potency anchor at pChEMBL 10.3.

Use CHEMBL2111930 as the tractability anchor when discussing potency (pChEMBL 10.3).

Activity source · ChEMBL 36 via Core Engine
10 approved pChEMBL 10.3
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Adenosine receptor A2a matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P30543, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

2563
Total Compounds
354
Total Assays
10
Approved Drugs
IC50: 59.0, KI: 2436.0, EC50: 73.0, KD: 19.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL2111930
 10.3 Kd —
No preferred name
CHEMBL4203542
 10.3 Ki —
No preferred name
CHEMBL4217582
 10.2 Ki —
No preferred name
CHEMBL373700
 9.7 Ki —
No preferred name
CHEMBL327708
 9.6 Kd —

Approved Drugs

Structure Compound First Approval
ISTRADEFYLLINE
CHEMBL431770
 2013
REGADENOSON ANHYDROUS
CHEMBL317052
 2008
ADENOSINE
CHEMBL477
 1989
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:19:57Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL302