Adenosine receptor A2a · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P30543. Use UniProt P30543 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P30543 as the stable identity anchor, then attach disease evidence before program review.
Adenosine receptor A2a
Review this target as Adenosine receptor A2a, mapped to UniProt P30543. Sequence length is 410 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Adenosine receptor A2a as ChEMBL target CHEMBL302, mapped to UniProt P30543. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Adenosine receptor A2a |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P30543 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Adenosine receptor A2a |
| UniProt Accession | P30543 |
| Component Type | Protein |
| Sequence Length | 410 aa |
Adenosine receptor A2a
Review this target as Adenosine receptor A2a, mapped to UniProt P30543. Sequence length is 410 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2111930 | 10.32 | Kd | 0.048 | Preclinical |
| CHEMBL4203542 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL4217582 | 10.22 | Ki | 0.06 | Preclinical |
| CHEMBL373700 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL327708 | 9.64 | Kd | 0.23 | Preclinical |
| CHEMBL144360 | 9.57 | Kd | 0.27 | Preclinical |
| CHEMBL4205341 | 9.55 | Ki | 0.28 | Preclinical |
| CHEMBL373560 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL222784 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL222868 | 9.52 | Ki | 0.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 159 | 788 | 6.1 |
| single protein format | 64 | 309 | 7.0 |
| assay format | 57 | 476 | 6.6 |
| cell-based format | 19 | 65 | 7.1 |
| tissue-based format | 17 | 223 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 15 | 32 | 6.7 |
| assay format | 11 | 67 | 7.1 |
| cell-based format | 8 | 5 | 7.1 |
| cell membrane format | 3 | 34 | 6.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 2 | 6.5 |