Assay Detail

CHEMBL645901

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity at Alpha-2 adrenergic receptor

ChEMBL ↗

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Target

Adenosine receptor A2b (CHEMBL2592) ↗

Open DB target context

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Adenosine receptor A2b (CHEMBL2592) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Adenosine receptor A2b

CHEMBL2592

Anchored from Assay target.

Protein identity Adenosine receptor A2b

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Adenosine receptor A2b (CHEMBL2592) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists.

Glase SA, Akunne HC, Georgic LM, Heffner TG, MacKenzie RG, Manley PJ, Pugsley TA, Wise LD.
J Med Chem (1997) 40 : 1771 -1772
PubMed 9191952 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	6.75	6.75

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL45244	PD-168,077	—	1	6.75

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL45244	PD-168,077	Ki	=	177.0	nM	6.75