Assay Detail
Binding
CHEMBL645919
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Binding affinity against adenosine A2 receptor from human platelet membranes using [3H]NECA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.26 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410873 | — | — | 1 | 8.24 |
| CHEMBL2113510 | — | — | 1 | 8.14 |
| CHEMBL319387 | — | — | 1 | 8.09 |
| CHEMBL2113507 | — | — | 1 | 7.68 |
| CHEMBL2113496 | — | — | 1 | 7.40 |
| CHEMBL464859 | NECA | — | 1 | 7.16 |
| CHEMBL139000 | (R)-PIA | — | 1 | 5.77 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410873 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL2113510 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL319387 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL2113507 | — | Ki | = | 20.8 | nM | 7.68 |
| CHEMBL2113496 | — | Ki | = | 39.9 | nM | 7.40 |
| CHEMBL464859 | NECA | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL139000 | (R)-PIA | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 2400.0 | nM | 5.62 |