Assay Detail
Binding
CHEMBL645954
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In vitro alpha-1 adrenergic receptor binding affinity was determined on calf frontal cortex membrane preparation
30
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Frontal cortex |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of new 2-(4,5-dihydro-1H-imidazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 5.52 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274784 | — | — | 1 | 6.15 |
| CHEMBL276035 | — | — | 1 | 6.00 |
| CHEMBL13810 | — | — | 1 | 5.84 |
| CHEMBL14242 | — | — | 3 | 5.59 |
| CHEMBL13893 | — | — | 1 | 5.46 |
| CHEMBL418716 | — | — | 1 | 5.34 |
| CHEMBL14110 | — | — | 1 | 5.32 |
| CHEMBL60031 | — | — | 1 | 5.25 |
| CHEMBL14154 | — | — | 1 | 5.03 |
| CHEMBL62107 | — | — | 1 | - |
| CHEMBL13793 | — | — | 1 | - |
| CHEMBL60186 | — | — | 1 | - |
| CHEMBL58187 | — | — | 1 | - |
| CHEMBL13987 | — | — | 1 | - |
| CHEMBL13858 | — | — | 1 | - |
| CHEMBL13591 | — | — | 1 | - |
| CHEMBL61689 | — | — | 1 | - |
| CHEMBL13955 | — | — | 1 | - |
| CHEMBL58186 | — | — | 1 | - |
| CHEMBL267074 | — | — | 1 | - |
| CHEMBL13938 | — | — | 1 | - |
| CHEMBL13940 | — | — | 1 | - |
| CHEMBL274315 | — | — | 1 | - |
| CHEMBL13721 | — | — | 1 | - |
| CHEMBL13958 | — | — | 1 | - |
| CHEMBL300388 | — | — | 1 | - |
| CHEMBL13918 | — | — | 1 | - |
| CHEMBL62095 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274784 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL276035 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL13810 | — | Ki | = | 1460.0 | nM | 5.84 |
| CHEMBL14242 | — | Ki | = | 2540.0 | nM | 5.59 |
| CHEMBL13893 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL418716 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL14110 | — | Ki | = | 4740.0 | nM | 5.32 |
| CHEMBL60031 | — | Ki | = | 5660.0 | nM | 5.25 |
| CHEMBL14242 | — | Ki | = | 5910.0 | nM | 5.23 |
| CHEMBL14154 | — | Ki | = | 9400.0 | nM | 5.03 |
| CHEMBL14242 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL58186 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL62095 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL13918 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL62107 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL13591 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL13858 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL13793 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL13987 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL58187 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL13938 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL13955 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL13940 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL274315 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL60186 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL13721 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL13958 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL61689 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL300388 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL267074 | — | Ki | > | 10000.0 | nM | - |