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Compound Detail

CHEMBL13893

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c1ccc(CN2CC(C3=NCCN3)Oc3ccccc32)cc1

Basic Information

ChEMBL ID CHEMBL13893
Phase Preclinical
Structure Type MOL
InChI Key ZUSUAMQUCDPBNO-UHFFFAOYSA-N
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

293.4
MW (Da)
2.46
ALogP
4
HBA
1
HBD
36.9
PSA (Ų)
0.94
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H19N3O
MW 293.37
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -0.57

Activity Summary

Ki 5 meas. best 5.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Ki 5.89 5.675 1300.0 2
Nischarin
CHEMBL3923
Ki 5.8 5.6733 1584.9 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12723959 10.1021/jm021050c Rattus norvegicus 4
12723959 10.1021/jm021050c Nischarin 2
12723959 10.1021/jm021050c Unchecked 2
10737743 10.1021/jm991124t Nischarin 1

Data from ChEMBL 36 via Core Engine