Assay Detail
Binding
CHEMBL648056
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro alpha-2 adrenergic receptor binding affinity was determined on calf frontal cortex membrane preparation
31
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Frontal cortex |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of new 2-(4,5-dihydro-1H-imidazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 6.79 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13958 | — | — | 1 | 8.14 |
| CHEMBL58187 | — | — | 1 | 7.98 |
| CHEMBL62095 | — | — | 1 | 7.91 |
| CHEMBL60031 | — | — | 1 | 7.58 |
| CHEMBL13955 | — | — | 1 | 7.54 |
| CHEMBL276035 | — | — | 1 | 7.52 |
| CHEMBL14242 | — | — | 3 | 7.48 |
| CHEMBL13810 | — | — | 1 | 7.28 |
| CHEMBL13987 | — | — | 1 | 7.16 |
| CHEMBL14028 | — | — | 1 | 7.13 |
| CHEMBL267074 | — | — | 1 | 7.01 |
| CHEMBL13940 | — | — | 1 | 6.88 |
| CHEMBL13591 | — | — | 1 | 6.84 |
| CHEMBL14110 | — | — | 1 | 6.84 |
| CHEMBL13793 | — | — | 1 | 6.64 |
| CHEMBL58186 | — | — | 1 | 6.58 |
| CHEMBL274315 | — | — | 1 | 6.54 |
| CHEMBL274784 | — | — | 1 | 6.47 |
| CHEMBL60186 | — | — | 1 | 6.44 |
| CHEMBL61689 | — | — | 1 | 6.40 |
| CHEMBL13893 | — | — | 1 | 5.89 |
| CHEMBL418716 | — | — | 1 | 5.67 |
| CHEMBL14154 | — | — | 1 | 5.17 |
| CHEMBL62107 | — | — | 1 | 5.12 |
| CHEMBL13858 | — | — | 1 | 4.89 |
| CHEMBL13938 | — | — | 1 | - |
| CHEMBL13721 | — | — | 1 | - |
| CHEMBL300388 | — | — | 1 | - |
| CHEMBL13918 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13958 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL58187 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL62095 | — | Ki | = | 12.4 | nM | 7.91 |
| CHEMBL60031 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL13955 | — | Ki | = | 28.6 | nM | 7.54 |
| CHEMBL276035 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL14242 | — | Ki | = | 32.9 | nM | 7.48 |
| CHEMBL13810 | — | Ki | = | 52.5 | nM | 7.28 |
| CHEMBL14242 | — | Ki | = | 68.2 | nM | 7.17 |
| CHEMBL13987 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL14028 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL267074 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL14242 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL13940 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL14110 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL13591 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL13793 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL58186 | — | Ki | = | 263.0 | nM | 6.58 |
| CHEMBL274315 | — | Ki | = | 287.0 | nM | 6.54 |
| CHEMBL274784 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL60186 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL61689 | — | Ki | = | 402.0 | nM | 6.40 |
| CHEMBL13893 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL418716 | — | Ki | = | 2150.0 | nM | 5.67 |
| CHEMBL14154 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL62107 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL13858 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL13938 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL13721 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL300388 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL13918 | — | Ki | > | 10000.0 | nM | - |