Assay Detail
Binding
CHEMBL646063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Angiotensin I converting enzyme
11
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Synthesis and biological properties of (carboxyalkyl)amino-substituted bicyclic lactam inhibitors of angiotensin converting enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.49 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL543766 | — | — | 4 | 8.77 |
| CHEMBL2093973 | — | — | 2 | 8.40 |
| CHEMBL39538 | — | — | 1 | 8.35 |
| CHEMBL2094046 | — | — | 1 | 7.21 |
| CHEMBL558003 | — | — | 2 | 6.21 |
| CHEMBL2447978 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL543766 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL543766 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2093973 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL39538 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL543766 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL2093973 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL543766 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2094046 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL558003 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL558003 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2447978 | — | IC50 | = | 5100.0 | nM | 5.29 |