Assay Detail
Binding
CHEMBL646094
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Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel thiophene derivatives for the treatment of benign prostatic hyperplasia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.29 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420184 | — | — | 1 | 7.92 |
| CHEMBL69339 | — | — | 1 | 7.89 |
| CHEMBL68241 | — | — | 1 | 7.82 |
| CHEMBL305029 | — | — | 1 | 7.75 |
| CHEMBL70178 | — | — | 1 | 7.64 |
| CHEMBL69848 | — | — | 1 | 7.60 |
| CHEMBL421297 | — | — | 1 | 7.33 |
| CHEMBL67932 | — | — | 1 | 7.04 |
| CHEMBL67713 | — | — | 1 | 7.04 |
| CHEMBL66823 | — | — | 1 | 6.89 |
| CHEMBL302495 | — | — | 1 | 6.86 |
| CHEMBL418882 | — | — | 1 | 6.58 |
| CHEMBL303485 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420184 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL69339 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL68241 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL305029 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL70178 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL69848 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL421297 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL67932 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL67713 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL66823 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL302495 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL418882 | — | Ki | = | 262.0 | nM | 6.58 |
| CHEMBL303485 | — | Ki | = | 339.0 | nM | 6.47 |