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Compound Detail

CHEMBL303485

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CC(C)Oc1ccccc1N1CCN(Cc2cc(CO)cs2)CC1

Basic Information

ChEMBL ID CHEMBL303485
Phase Preclinical
Structure Type MOL
InChI Key FHHPURZYJUQVBM-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

346.5
MW (Da)
3.35
ALogP
5
HBA
1
HBD
35.9
PSA (Ų)
0.87
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H26N2O2S
MW 346.50
Aromatic Rings 2
Heavy Atoms 24
NP-Likeness -1.35

Activity Summary

Ki 2 meas. best 6.48

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-1A adrenergic receptor
CHEMBL229
Ki 6.48 6.48 331.0 1
Alpha-1D adrenergic receptor
CHEMBL223
Ki 6.47 6.47 339.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12127524 10.1016/s0960-894x(02)00347-5 Alpha-1A adrenergic receptor 1
12127524 10.1016/s0960-894x(02)00347-5 Alpha-1B adrenergic receptor 1
12127524 10.1016/s0960-894x(02)00347-5 Alpha-1D adrenergic receptor 1
12127524 10.1016/s0960-894x(02)00347-5 Adrenergic receptors; alpha-1 A & B 1
12127524 10.1016/s0960-894x(02)00347-5 Alpha adrenergic receptor (1a and 1d) 1

Data from ChEMBL 36 via Core Engine