Assay Detail
Binding
CHEMBL652815
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]HEAT from COS cell membranes expressing human Alpha-1A adrenergic receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel thiophene derivatives for the treatment of benign prostatic hyperplasia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.76 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69848 | — | — | 1 | 9.70 |
| CHEMBL305029 | — | — | 1 | 9.52 |
| CHEMBL67713 | — | — | 1 | 9.30 |
| CHEMBL421297 | — | — | 1 | 8.74 |
| CHEMBL68241 | — | — | 1 | 7.92 |
| CHEMBL420184 | — | — | 1 | 7.85 |
| CHEMBL69339 | — | — | 1 | 7.75 |
| CHEMBL70178 | — | — | 1 | 7.40 |
| CHEMBL67932 | — | — | 1 | 6.89 |
| CHEMBL302495 | — | — | 1 | 6.70 |
| CHEMBL303485 | — | — | 1 | 6.48 |
| CHEMBL66823 | — | — | 1 | 6.38 |
| CHEMBL418882 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69848 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL305029 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL67713 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL421297 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL68241 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL420184 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL69339 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL70178 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL67932 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL302495 | — | Ki | = | 202.0 | nM | 6.70 |
| CHEMBL303485 | — | Ki | = | 331.0 | nM | 6.48 |
| CHEMBL66823 | — | Ki | = | 419.0 | nM | 6.38 |
| CHEMBL418882 | — | Ki | = | 578.0 | nM | 6.24 |