Assay Detail
Binding
CHEMBL646108
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Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Arylpiperazine substituted heterocycles as selective alpha(1a) adrenergic antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.50 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80109 | — | — | 1 | 7.46 |
| CHEMBL310890 | — | — | 1 | 7.40 |
| CHEMBL309969 | — | — | 1 | 7.18 |
| CHEMBL310768 | — | — | 1 | 6.98 |
| CHEMBL81661 | — | — | 1 | 6.77 |
| CHEMBL79817 | — | — | 1 | 6.54 |
| CHEMBL79990 | — | — | 1 | 5.96 |
| CHEMBL81093 | — | — | 1 | 5.84 |
| CHEMBL80125 | — | — | 1 | 5.51 |
| CHEMBL80036 | — | — | 1 | 5.38 |
| CHEMBL79940 | — | — | 1 | - |
| CHEMBL83791 | — | — | 1 | - |
| CHEMBL82480 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80109 | — | Ki | = | 34.5 | nM | 7.46 |
| CHEMBL310890 | — | Ki | = | 39.5 | nM | 7.40 |
| CHEMBL309969 | — | Ki | = | 65.5 | nM | 7.18 |
| CHEMBL310768 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL81661 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL79817 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL79990 | — | Ki | = | 1107.0 | nM | 5.96 |
| CHEMBL81093 | — | Ki | = | 1435.0 | nM | 5.84 |
| CHEMBL80125 | — | Ki | = | 3064.0 | nM | 5.51 |
| CHEMBL80036 | — | Ki | = | 4142.0 | nM | 5.38 |
| CHEMBL79940 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL83791 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL82480 | — | Ki | > | 5000.0 | nM | - |