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Compound Detail

CHEMBL79990

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CC(C)Oc1ccccc1N1CCN(Cc2nc(CN3C(=O)c4ccccc4C3=O)co2)CC1

Basic Information

ChEMBL ID CHEMBL79990
Phase Preclinical
Structure Type MOL
InChI Key QUFMDMYSYWGKMF-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

460.5
MW (Da)
3.58
ALogP
7
HBA
0
HBD
79.1
PSA (Ų)
0.50
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H28N4O4
MW 460.53
Aromatic Rings 3
Heavy Atoms 34
NP-Likeness -1.31

Activity Summary

Ki 2 meas. best 6.53

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-1A adrenergic receptor
CHEMBL229
Ki 6.53 6.53 297.0 1
Alpha-1D adrenergic receptor
CHEMBL223
Ki 5.96 5.96 1107.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12161153 10.1016/s0960-894x(02)00436-5 Alpha-1A adrenergic receptor 1
12161153 10.1016/s0960-894x(02)00436-5 Alpha-1B adrenergic receptor 1
12161153 10.1016/s0960-894x(02)00436-5 Alpha-1D adrenergic receptor 1
12161153 10.1016/s0960-894x(02)00436-5 Adrenergic receptors; alpha-1 A & B 1
12161153 10.1016/s0960-894x(02)00436-5 Alpha adrenergic receptor (1a and 1d) 1

Data from ChEMBL 36 via Core Engine