Assay Detail
Binding
CHEMBL646121
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Tested for its inhibitory activity against alpha-1 adrenoceptor in guinea pig ileum
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.22 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL544765 | — | — | 1 | 5.67 |
| CHEMBL306751 | — | — | 2 | 5.24 |
| CHEMBL542155 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL544765 | — | EC50 | = | 2113.0 | nM | 5.67 |
| CHEMBL306751 | — | EC50 | = | 5793.0 | nM | 5.24 |
| CHEMBL306751 | — | EC50 | = | 8273.0 | nM | 5.08 |
| CHEMBL542155 | — | EC50 | = | 12692.0 | nM | 4.90 |