Assay Detail

CHEMBL646126

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Effective concentration for inhibition of neurotransmission in field-stimulated, reserpine-pretreated guinea pig ileum.

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Tissue	Ileum
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.

Ruffolo RR, Bondinell W, Hieble JP.
J Med Chem (1995) 38 : 3681 -3716
PubMed 7562902 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	6.28	7.72

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL677	LEVONORDEFRIN	4.0	1	7.72
CHEMBL1437	NOREPINEPHRINE	4.0	1	4.84

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL677	LEVONORDEFRIN	EC50	=	19.0	nM	7.72
CHEMBL1437	NOREPINEPHRINE	EC50	=	14500.0	nM	4.84