Assay Detail
Binding
CHEMBL646132
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Binding affinity against alpha-1 adrenergic receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.60 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12129 | — | — | 1 | 8.00 |
| CHEMBL12152 | — | — | 1 | 7.80 |
| CHEMBL12124 | — | — | 1 | 7.20 |
| CHEMBL12311 | — | — | 1 | 6.10 |
| CHEMBL11824 | — | — | 1 | 5.30 |
| CHEMBL11787 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12129 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL12152 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL12124 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL12311 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL11824 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL11787 | — | IC50 | = | 6309.57 | nM | 5.20 |