Assay Detail
Binding
CHEMBL646137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards human adenosine deaminase (ADA)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.04 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93280 | — | — | 1 | 8.11 |
| CHEMBL92404 | — | — | 1 | 8.01 |
| CHEMBL93560 | — | — | 1 | 7.96 |
| CHEMBL328139 | — | — | 1 | 7.89 |
| CHEMBL327830 | — | — | 1 | 6.17 |
| CHEMBL93647 | — | — | 1 | 5.92 |
| CHEMBL329433 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93280 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL92404 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL93560 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL328139 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL327830 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL93647 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL329433 | — | Ki | = | 5900.0 | nM | 5.23 |