Assay Detail
Binding
CHEMBL646140
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Inhibition of human adenosine deaminase (ADA)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.22 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340297 | — | — | 1 | 8.31 |
| CHEMBL125386 | — | — | 1 | 8.12 |
| CHEMBL93280 | — | — | 1 | 8.11 |
| CHEMBL121939 | — | — | 1 | 7.96 |
| CHEMBL123620 | — | — | 1 | 7.92 |
| CHEMBL340557 | — | — | 1 | 7.89 |
| CHEMBL125038 | — | — | 1 | 7.89 |
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 7.80 |
| CHEMBL340086 | — | — | 1 | 7.77 |
| CHEMBL332298 | — | — | 1 | 7.77 |
| CHEMBL334197 | — | — | 1 | 7.62 |
| CHEMBL334172 | — | — | 1 | 7.58 |
| CHEMBL338076 | — | — | 1 | 7.52 |
| CHEMBL124728 | — | — | 1 | 7.47 |
| CHEMBL121714 | — | — | 1 | 7.42 |
| CHEMBL333809 | — | — | 1 | 7.26 |
| CHEMBL125208 | — | — | 1 | 7.24 |
| CHEMBL420174 | — | — | 1 | 7.04 |
| CHEMBL125275 | — | — | 1 | 6.62 |
| CHEMBL93647 | — | — | 1 | 5.92 |
| CHEMBL122016 | — | — | 1 | 5.89 |
| CHEMBL435971 | — | — | 1 | 5.72 |
| CHEMBL13696 | FR-221647 | — | 1 | 5.23 |
| CHEMBL332440 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340297 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL125386 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL93280 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL121939 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL123620 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL340557 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL125038 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL441738 | AFAMELANOTIDE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL340086 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL332298 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL334197 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL334172 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL338076 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL124728 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL121714 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL333809 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL125208 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL420174 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL125275 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL93647 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL122016 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL435971 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL13696 | FR-221647 | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL332440 | — | Ki | = | 6200.0 | nM | 5.21 |