Assay Detail
Binding
CHEMBL646224
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In vitro inhibition of Angiotensin I converting enzyme isolated from rabbit lung extract.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Lung |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Dual metalloprotease inhibitors. 6. Incorporation of bicyclic and substituted monocyclic azepinones as dipeptide surrogates in angiotensin-converting enzyme/neutral endopeptidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.69 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41201 | — | — | 1 | 8.30 |
| CHEMBL434070 | — | — | 1 | 8.30 |
| CHEMBL148155 | — | — | 1 | 8.15 |
| CHEMBL104054 | — | — | 1 | 8.10 |
| CHEMBL345021 | — | — | 1 | 8.00 |
| CHEMBL39775 | — | — | 1 | 7.96 |
| CHEMBL147043 | — | — | 1 | 7.96 |
| CHEMBL299639 | — | — | 1 | 7.92 |
| CHEMBL343191 | — | — | 1 | 7.85 |
| CHEMBL318096 | — | — | 1 | 7.80 |
| CHEMBL147153 | — | — | 1 | 7.77 |
| CHEMBL299169 | — | — | 1 | 7.66 |
| CHEMBL146823 | — | — | 1 | 7.64 |
| CHEMBL146371 | — | — | 1 | 7.60 |
| CHEMBL149442 | — | — | 1 | 7.60 |
| CHEMBL144659 | — | — | 1 | 7.58 |
| CHEMBL287896 | — | — | 1 | 7.52 |
| CHEMBL357932 | — | — | 1 | 6.32 |
| CHEMBL356577 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41201 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL434070 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL148155 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL104054 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL345021 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL39775 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL147043 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL299639 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL343191 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL318096 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL147153 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL299169 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL146823 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL146371 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL149442 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL144659 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL287896 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL357932 | — | IC50 | = | 479.0 | nM | 6.32 |
| CHEMBL356577 | — | IC50 | = | 907.0 | nM | 6.04 |