Assay Detail
Functional
CHEMBL646228
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Antagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.09 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25554 | — | — | 1 | 8.16 |
| CHEMBL44403 | — | — | 1 | 7.58 |
| CHEMBL42472 | — | — | 1 | 7.54 |
| CHEMBL13647 | BMY-7378 | — | 1 | 7.48 |
| CHEMBL42558 | — | — | 1 | 7.17 |
| CHEMBL42231 | — | — | 1 | 6.96 |
| CHEMBL43905 | — | — | 1 | 6.81 |
| CHEMBL40325 | — | — | 1 | 6.52 |
| CHEMBL297106 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25554 | — | Kd | = | 6.918 | nM | 8.16 |
| CHEMBL44403 | — | Kd | = | 26.3 | nM | 7.58 |
| CHEMBL42472 | — | Kd | = | 28.84 | nM | 7.54 |
| CHEMBL13647 | BMY-7378 | Kd | = | 33.11 | nM | 7.48 |
| CHEMBL42558 | — | Kd | = | 67.61 | nM | 7.17 |
| CHEMBL42231 | — | Kd | = | 109.65 | nM | 6.96 |
| CHEMBL43905 | — | Kd | = | 154.88 | nM | 6.81 |
| CHEMBL40325 | — | Kd | = | 302.0 | nM | 6.52 |
| CHEMBL297106 | — | Kd | = | 2511.89 | nM | 5.60 |