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Assay Detail

CHEMBL646296

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonistic activity against Alpha-1 adrenergic receptor in the epidermal portion of the rat vas deferens
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Tissue Vas deferens
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adrenergic receptor alpha-1 (CHEMBL1907610)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Structure-activity relationships for 2-substituted imidazoles as alpha 2-adrenoceptor antagonists.
Caroon JM, Clark RD, Kluge AF, Olah R, Repke DB, Unger SH, Michel AD, Whiting RL.
J Med Chem (1982) 25 : 666 -670
PubMed 6124635 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 2 5.00 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1203734 1 5.00
CHEMBL1203738 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1203734 Kd = 10000.0 nM 5.00
CHEMBL1203738 Kd = 10000.0 nM 5.00