Assay Detail
Functional
CHEMBL646301
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Alpha-1 adrenergic receptor antagonist activity against agonist (norepinephrine) in isolated rat vas deferens
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
2-[[[2-(2,6-Dimethoxyphenoxy)ethyl]amino]-methyl] -1,4-benzoxathian: a new antagonist with high potency and selectivity toward alpha 1-adrenoreceptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.94 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL544713 | BENOXATHIAN HYDROCHLORIDE | — | 1 | 9.26 |
| CHEMBL556001 | 2- (2,6-DIMETHOXYPHENOXYETHYL)AMINOMETHYL-1,4-BENZODIOXANE HYDROCHLORIDE (WB 4101) | — | 1 | 8.83 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 8.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL544713 | BENOXATHIAN HYDROCHLORIDE | Kd | = | 0.5495 | nM | 9.26 |
| CHEMBL556001 | 2- (2,6-DIMETHOXYPHENOXYETHYL)AMINOMETHYL-1,4-BENZODIOXANE HYDROCHLORIDE (WB 4101) | Kd | = | 1.479 | nM | 8.83 |
| CHEMBL2 | PRAZOSIN | Kd | = | 1.82 | nM | 8.74 |