Assay Detail
Binding
CHEMBL646326
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Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase values
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member A1 (CHEMBL4049) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.88 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7480 | ALCONIL | — | 1 | 7.57 |
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 6.27 |
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 5.82 |
| CHEMBL7679 | PONALRESTAT | 2.0 | 1 | 5.70 |
| CHEMBL433 | VALPROATE SODIUM | 4.0 | 1 | 4.05 |
| CHEMBL1159684 | MENADIONE SULFUROUS ACID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7480 | ALCONIL | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL436 | TOLRESTAT | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL56337 | EPALRESTAT | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL7679 | PONALRESTAT | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL433 | VALPROATE SODIUM | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL1159684 | MENADIONE SULFUROUS ACID | IC50 | = | 490000.0 | nM | - |