Aldo-keto reductase family 1 member A1 · SINGLE PROTEIN · Sus scrofa
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As of 2026-09-13Protein identity stays anchored to UniProt P50578. Use UniProt P50578 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P50578 as the stable identity anchor, then attach disease evidence before program review.
Aldo-keto reductase family 1 member A1
Review this target as Aldo-keto reductase family 1 member A1, mapped to UniProt P50578. Sequence length is 325 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Aldo-keto reductase family 1 member A1 as ChEMBL target CHEMBL4049, mapped to UniProt P50578. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Aldo-keto reductase family 1 member A1 is the right protein anchor across sources, using UniProt P50578 as the stable mapping.
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| Preferred Name | Aldo-keto reductase family 1 member A1 |
| Target Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
| UniProt | P50578 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Aldo-keto reductase family 1 member A1 |
| UniProt Accession | P50578 |
| Component Type | Protein |
| Sequence Length | 325 aa |
Aldo-keto reductase family 1 member A1
Review this target as Aldo-keto reductase family 1 member A1, mapped to UniProt P50578. Sequence length is 325 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL269550 | 9.32 | IC50 | 0.48 | Preclinical |
| CHEMBL7480 | 7.57 | IC50 | 27.0 | Preclinical |
| CHEMBL273910 | 7.4 | IC50 | 40.0 | Clinical |
| CHEMBL436 | 6.27 | IC50 | 540.0 | Approved |
| CHEMBL56337 | 5.82 | IC50 | 1500.0 | Approved |
| CHEMBL266497 | 5.72 | IC50 | 1900.0 | Clinical |
| CHEMBL7679 | 5.7 | IC50 | 2000.0 | Clinical |
| CHEMBL84446 | 5.6 | IC50 | 2500.0 | Clinical |
| CHEMBL396176 | 5.27 | IC50 | 5400.0 | Preclinical |
| CHEMBL449129 | 4.95 | IC50 | 11300.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 10 | 15 | 5.8 |