Assay Detail
Binding
CHEMBL646332
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The ability to displace [3H]clonidine from the Alpha-2 adrenergic receptor was determined in rat brain membrane
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.76 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 8.72 |
| CHEMBL31410 | CORYNANTHEINE | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL31410 | CORYNANTHEINE | Ki | = | 15800.0 | nM | 4.80 |