Assay Detail
Binding
CHEMBL646358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]NECA binding to Adenosine A2 receptor of rat striatal membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.08 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1688963 | ISOGUANOSINE | — | 1 | 6.48 |
| CHEMBL605025 | — | — | 1 | 6.22 |
| CHEMBL603994 | — | — | 1 | 5.91 |
| CHEMBL605024 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1688963 | ISOGUANOSINE | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL605025 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL603994 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL605024 | — | Ki | = | 2000.0 | nM | 5.70 |