Assay Detail
Binding
CHEMBL646360
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via Adenosine A2 receptor in rat PC12 membranes
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | PC-12 |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 5.65 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274855 | — | — | 1 | 7.14 |
| CHEMBL160369 | — | — | 1 | 6.68 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 6.60 |
| CHEMBL9069 | — | — | 1 | 6.60 |
| CHEMBL321505 | — | — | 1 | 6.35 |
| CHEMBL22042 | — | — | 1 | 6.00 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | — | 1 | 5.80 |
| CHEMBL158507 | — | — | 1 | 5.64 |
| CHEMBL418375 | — | — | 1 | 5.42 |
| CHEMBL281811 | — | — | 1 | 5.39 |
| CHEMBL8488 | — | — | 1 | 5.30 |
| CHEMBL278332 | — | — | 1 | 5.28 |
| CHEMBL157655 | — | — | 1 | 5.27 |
| CHEMBL20483 | — | — | 1 | 5.25 |
| CHEMBL418333 | — | — | 1 | 4.96 |
| CHEMBL281633 | — | — | 1 | 4.77 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.77 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.43 |
| CHEMBL20993 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274855 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL160369 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL9069 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL321505 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL22042 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL158507 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL418375 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL281811 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL8488 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL278332 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL157655 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL20483 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL418333 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL281633 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL113 | CAFFEINE | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL20993 | — | Ki | = | 150000.0 | nM | - |