Assay Detail
Binding
CHEMBL646365
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Binding affinity at Adenosine A2 receptor from rat striatal membranes by N-[3H] ethyladenosin-5'- uronamide displacement.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.23 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27508 | — | — | 1 | 8.11 |
| CHEMBL27203 | — | — | 1 | 7.75 |
| CHEMBL120350 | — | — | 1 | 6.60 |
| CHEMBL116486 | — | — | 1 | 6.54 |
| CHEMBL84144 | — | — | 1 | 6.48 |
| CHEMBL312352 | — | — | 1 | 6.48 |
| CHEMBL82589 | — | — | 1 | 6.42 |
| CHEMBL313780 | — | — | 1 | 6.39 |
| CHEMBL84363 | — | — | 1 | 6.37 |
| CHEMBL310557 | — | — | 1 | 6.37 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 6.23 |
| CHEMBL82417 | — | — | 1 | 5.70 |
| CHEMBL84545 | — | — | 1 | 5.57 |
| CHEMBL418101 | — | — | 1 | 5.29 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.80 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.57 |
| CHEMBL312857 | — | — | 1 | - |
| CHEMBL83822 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27508 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL27203 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL120350 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL116486 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL84144 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL312352 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL82589 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL313780 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL84363 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL310557 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL82417 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL84545 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL418101 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL113 | CAFFEINE | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL312857 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL83822 | — | Ki | > | 100000.0 | nM | - |