Assay Detail
Binding
CHEMBL646406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Aminopeptidase N activity in pig kidney with 10 nM [3H]Leu-enkephalin as substrate
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Kidney |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New kelatorphan-related inhibitors of enkephalin metabolism: improved antinociceptive properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.61 | 7.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2114408 | — | — | 1 | 7.65 |
| CHEMBL2114407 | — | — | 1 | 7.49 |
| CHEMBL290337 | — | — | 1 | 7.15 |
| CHEMBL290366 | — | — | 1 | 6.92 |
| CHEMBL37418 | — | — | 1 | 6.89 |
| CHEMBL36094 | — | — | 2 | 6.46 |
| CHEMBL37921 | — | — | 1 | 6.44 |
| CHEMBL2115347 | — | — | 1 | 6.40 |
| CHEMBL36841 | — | — | 1 | 6.30 |
| CHEMBL440104 | — | — | 1 | 6.17 |
| CHEMBL2115348 | — | — | 1 | 5.84 |
| CHEMBL417878 | — | — | 1 | 5.82 |
| CHEMBL16779 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2114408 | — | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL2114407 | — | IC50 | = | 32.5 | nM | 7.49 |
| CHEMBL290337 | — | IC50 | = | 71.5 | nM | 7.15 |
| CHEMBL290366 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL37418 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL36094 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL37921 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2115347 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL36094 | — | IC50 | = | 445.0 | nM | 6.35 |
| CHEMBL36841 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL440104 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL2115348 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL417878 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL16779 | — | IC50 | = | 2000.0 | nM | - |