Assay Detail
Binding
CHEMBL646411
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for A+B stereoisomer)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.49 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159947 | — | — | 1 | 8.66 |
| CHEMBL39404 | — | — | 1 | 8.64 |
| CHEMBL39422 | — | — | 1 | 8.54 |
| CHEMBL290357 | — | — | 1 | 8.49 |
| CHEMBL36588 | — | — | 1 | 8.42 |
| CHEMBL288597 | — | — | 1 | 8.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159947 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL39404 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL39422 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL290357 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL36588 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL288597 | — | Ki | = | 6.3 | nM | 8.20 |