Assay Detail
Binding
CHEMBL646416
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Inhibition of aminopeptidase N (APN)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.72 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27040 | — | — | 1 | 7.46 |
| CHEMBL28124 | — | — | 1 | 6.92 |
| CHEMBL28650 | AMASTATIN | — | 1 | 6.70 |
| CHEMBL27519 | — | — | 1 | 6.68 |
| CHEMBL281321 | — | — | 1 | 5.72 |
| CHEMBL26376 | — | — | 1 | 5.64 |
| CHEMBL282364 | — | — | 1 | 5.57 |
| CHEMBL283227 | — | — | 1 | 5.42 |
| CHEMBL27824 | — | — | 1 | 5.35 |
| CHEMBL25915 | — | — | 1 | 5.14 |
| CHEMBL27656 | — | — | 1 | 4.77 |
| CHEMBL26382 | — | — | 1 | 4.60 |
| CHEMBL26032 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27040 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL28124 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL28650 | AMASTATIN | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL27519 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL281321 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL26376 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL282364 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL283227 | — | Ki | = | 3850.0 | nM | 5.42 |
| CHEMBL27824 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL25915 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL27656 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL26382 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL26032 | — | Ki | = | 45000.0 | nM | 4.35 |