Compound Detail
CHEMBL27040
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Basic Information
| ChEMBL ID | CHEMBL27040 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JUUKLUKHLXGEGW-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
231.4
MW (Da)
1.91
ALogP
3
HBA
3
HBD
63.3
PSA (Ų)
0.63
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Aminopeptidase N CHEMBL1907 | Ki | 7.46 | 7.46 | 35.0 | 1 |
| Aminopeptidase N CHEMBL2590 | Ki | 7.46 | 7.46 | 35.0 | 1 |
| Glutamyl aminopeptidase CHEMBL3439 | Ki | 5.55 | 5.55 | 2800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Aminopeptidase N | Ki | = | 35.0 | nM | 7.46 | Inhibition of aminopeptidase N (APN) | 7909847 |
| Aminopeptidase N | Ki | = | 35.0 | nM | 7.46 | Inhibition of hog kidney APN using [3H]Tyr1-Leu5-enkephalin as substrate preincu... | 29630364 |
| Glutamyl aminopeptidase | Ki | = | 2800.0 | nM | 5.55 | Inhibition of aminopeptidase A (APA) | 7909847 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7909847 | 10.1021/jm00035a014 | Glutamyl aminopeptidase | 1 |
| 7909847 | 10.1021/jm00035a014 | Aminopeptidase N | 1 |
| 29630364 | 10.1021/acs.jmedchem.7b00782 | Unchecked | 1 |
| 29630364 | 10.1021/acs.jmedchem.7b00782 | Aminopeptidase N | 1 |
Data from ChEMBL 36 via Core Engine