Assay Detail
Binding
CHEMBL4194819
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hog kidney APN using [3H]Tyr1-Leu5-enkephalin as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by liquid scintillation counting method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of Aminopeptidase N Inhibitors as Anti-cancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.32 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101771 | — | — | 1 | 7.50 |
| CHEMBL27040 | — | — | 1 | 7.46 |
| CHEMBL317189 | — | — | 1 | 7.43 |
| CHEMBL28124 | — | — | 1 | 6.92 |
| CHEMBL101147 | — | — | 1 | 6.48 |
| CHEMBL282364 | — | — | 1 | 5.57 |
| CHEMBL102006 | — | — | 1 | 4.81 |
| CHEMBL4203901 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101771 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL27040 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL317189 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL28124 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL101147 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL282364 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL102006 | — | Ki | = | 15500.0 | nM | 4.81 |
| CHEMBL4203901 | — | Ki | = | 45000.0 | nM | 4.35 |