Assay Detail
Binding
CHEMBL646438
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In vitro binding affinity against human Adenosine A3 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The utilization of a unified pharmacophore query in the discovery of new antagonists of the adenosine receptor family.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.08 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88147 | — | — | 1 | 9.19 |
| CHEMBL52735 | — | — | 1 | 7.89 |
| CHEMBL89472 | — | — | 1 | 7.75 |
| CHEMBL114535 | — | — | 1 | 6.22 |
| CHEMBL114643 | — | — | 1 | 5.89 |
| CHEMBL326389 | — | — | 1 | 5.51 |
| CHEMBL89093 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88147 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL52735 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL89472 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL114535 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL114643 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL326389 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL89093 | — | Ki | = | 560.0 | nM | - |