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Compound Detail

CHEMBL89093

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Cc1ccc(-c2oc3ccc(Cl)cc3c(=O)c2Cl)c(OC(C)C)c1

Basic Information

ChEMBL ID CHEMBL89093
Phase Preclinical
Structure Type MOL
InChI Key PWGZOUCWGRTPSM-UHFFFAOYSA-N
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names

Molecular Properties

363.2
MW (Da)
5.86
ALogP
3
HBA
0
HBD
39.4
PSA (Ų)
0.58
QED
1
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H16Cl2O3
MW 363.24
Aromatic Rings 3
Heavy Atoms 24
NP-Likeness -0.18

Activity Summary

Ki 6 meas. best 9.25

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
Ki 9.25 7.75 0.6 2
Adenosine receptor A3
CHEMBL3360
Ki 5.26 5.26 5500.0 1
Adenosine receptor A1
CHEMBL318
Ki 4.0 4.0 100000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22468757 10.1021/jm300087j Adenosine receptor A3 3
22468757 10.1021/jm300087j Adenosine receptor A1 2
8863790 10.1021/jm960482i Adenosine receptor A2a 1
8863790 10.1021/jm960482i Adenosine receptor A3 1
8863790 10.1021/jm960482i Adenosine receptor A1 1
9258367 10.1021/jm970091j Adenosine receptor A1 1
9258367 10.1021/jm970091j Adenosine receptor A2a 1
9258367 10.1021/jm970091j Adenosine receptor A3 1
10636237 10.1016/s0960-894x(99)00583-1 Adenosine receptor A3 1
22468757 10.1021/jm300087j Adenosine receptor A2a 1
22468757 10.1021/jm300087j Adenosine receptor A2a and A3 1
22468757 10.1021/jm300087j Unchecked 1

Data from ChEMBL 36 via Core Engine