Assay Detail
Binding
CHEMBL646439
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Displacement of [125 I]AB-MECA from Adenosine A3 receptor expressed in HEK cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.44 | 7.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321579 | — | — | 1 | 7.67 |
| CHEMBL89852 | — | — | 1 | 7.65 |
| CHEMBL315458 | — | — | 1 | 7.12 |
| CHEMBL315984 | — | — | 1 | 6.96 |
| CHEMBL431232 | — | — | 1 | 6.37 |
| CHEMBL103433 | — | — | 1 | 6.12 |
| CHEMBL104198 | — | — | 1 | 5.88 |
| CHEMBL105672 | — | — | 1 | 5.56 |
| CHEMBL283013 | — | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321579 | — | Ki | = | 21.3 | nM | 7.67 |
| CHEMBL89852 | — | Ki | = | 22.2 | nM | 7.65 |
| CHEMBL315458 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL315984 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL431232 | — | Ki | = | 426.0 | nM | 6.37 |
| CHEMBL103433 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL104198 | — | Ki | = | 1310.0 | nM | 5.88 |
| CHEMBL105672 | — | Ki | = | 2770.0 | nM | 5.56 |
| CHEMBL283013 | — | Ki | = | 23500.0 | nM | 4.63 |