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Compound Detail

CHEMBL315458

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CCOC(=O)C1=C(c2ccccc2)N=C(C)/C(=C(/O)OCC)C1C#Cc1ccccc1

Basic Information

ChEMBL ID CHEMBL315458
Phase Preclinical
Structure Type MOL
InChI Key DGRFYZXGLMGURO-YYDJUVGSSA-N
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names

Molecular Properties

415.5
MW (Da)
4.91
ALogP
5
HBA
1
HBD
68.1
PSA (Ų)
0.43
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H25NO4
MW 415.49
Aromatic Rings 2
Heavy Atoms 31
NP-Likeness -0.57

Activity Summary

Ki 6 meas. best 7.12

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
Ki 7.12 7.12 75.0 3
Adenosine receptor A1
CHEMBL318
Ki 4.96 4.96 11000.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9258367 10.1021/jm970091j Adenosine receptor A1 1
9258367 10.1021/jm970091j Adenosine receptor A2a 1
9258367 10.1021/jm970091j Adenosine receptor A3 1
9258367 10.1021/jm970091j Unchecked 1
8917655 10.1021/jm960457c Adenosine receptor A1 1
8917655 10.1021/jm960457c Adenosine receptor A2a 1
8917655 10.1021/jm960457c Adenosine receptor A3 1
8917655 10.1021/jm960457c Unchecked 1
10447949 10.1021/jm980688e Adenosine receptor A1 1
10447949 10.1021/jm980688e Adenosine receptor A2a 1
10447949 10.1021/jm980688e Adenosine receptor A3 1
10447949 10.1021/jm980688e Unchecked 1

Data from ChEMBL 36 via Core Engine