Assay Detail
Binding
CHEMBL642194
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Displacement of [3H]-R-PIA from adenosine A1 receptor of rat brain membrane
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 4.92 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105672 | — | — | 1 | 6.11 |
| CHEMBL315984 | — | — | 1 | 5.23 |
| CHEMBL283013 | — | — | 1 | 5.18 |
| CHEMBL315458 | — | — | 1 | 4.96 |
| CHEMBL431232 | — | — | 1 | 4.79 |
| CHEMBL103433 | — | — | 1 | 4.60 |
| CHEMBL104198 | — | — | 1 | 4.50 |
| CHEMBL321579 | — | — | 1 | 4.50 |
| CHEMBL89852 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105672 | — | Ki | = | 785.0 | nM | 6.11 |
| CHEMBL315984 | — | Ki | = | 5930.0 | nM | 5.23 |
| CHEMBL283013 | — | Ki | = | 6660.0 | nM | 5.18 |
| CHEMBL315458 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL431232 | — | Ki | = | 16400.0 | nM | 4.79 |
| CHEMBL103433 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL104198 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL321579 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL89852 | — | Ki | = | 40100.0 | nM | 4.40 |