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Assay Detail

CHEMBL646465

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]Leu-enkephalin binding to aminopeptidase
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes.
Hernandez JF, Soleilhac JM, Roques BP, Fournié-Zaluski MC.
J Med Chem (1988) 31 : 1825 -1831
PubMed 2900898 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.53 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL37418 1 6.89
CHEMBL85320 KELATORPHAN 1 6.42
CHEMBL1907967 1 5.70
CHEMBL16779 1 5.70
CHEMBL57623 1 5.21
CHEMBL299588 2 5.21
CHEMBL55056 1 5.07
CHEMBL17107 1 4.00
CHEMBL1907791 1 -
CHEMBL1907790 1 -
CHEMBL1907793 1 -
CHEMBL1907968 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL37418 IC50 = 130.0 nM 6.89
CHEMBL85320 KELATORPHAN IC50 = 380.0 nM 6.42
CHEMBL1907967 IC50 = 2000.0 nM 5.70
CHEMBL16779 IC50 = 2000.0 nM 5.70
CHEMBL57623 IC50 = 6200.0 nM 5.21
CHEMBL299588 IC50 = 6100.0 nM 5.21
CHEMBL55056 IC50 = 8600.0 nM 5.07
CHEMBL17107 IC50 = 100000.0 nM 4.00
CHEMBL1907791 IC50 = 150000.0 nM -
CHEMBL1907790 IC50 ~ 20000.0 nM -
CHEMBL1907793 IC50 > 100000.0 nM -
CHEMBL299588 IC50 ~ 100000.0 nM -
CHEMBL1907968 IC50 ~ 4000000.0 nM -